P03-022 - Calprotec in chronic nonbacterial osteomyelitis
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P03-022 - Calprotec in chronic nonbacterial osteomyelitis
Introduction The cytoplasmic S100 proteins derived from cells of myeloid origin. Calprotectin (MRP8/14 protein complex) might be a biomarker either for autoinflammation and autoimmunopathy. Since autoinflammatory diseases might be a diagnostic challenge calprotectin may be helpful in the diagnosis of autoinflammatory diseases. Chronic nonbacterial osteomyelitis (CNO) is an autoinflammatory, non...
متن کاملPediatric chronic nonbacterial osteomyelitis.
BACKGROUND AND OBJECTIVES Little information is available concerning the natural history and optimal treatment of chronic nonbacterial osteomyelitis (CNO). We conducted a retrospective review to assess the clinical characteristics and treatment responses of a large cohort of pediatric CNO patients. METHODS Children diagnosed with CNO at 3 tertiary care centers in the United States between 198...
متن کاملChronic nonbacterial osteomyelitis in children
Chronic Nonbacterial Osteomyelitis (CNO) is an autoinflammatory disease that presents as recurrent flares of bone pain, sometimes febrile and with lytic radiological pictures. Extraarticular manifestations are also possible. We present a retrospective study of eleven children (ten females, one male), followed in Pediatric Orthopedic ward of the Caen University Hospital between 2001 and 2011. We...
متن کاملUpdate: Cytokine Dysregulation in Chronic Nonbacterial Osteomyelitis (CNO)
Chronic nonbacterial osteomyelitis (CNO) with its most severe form chronic recurrent multifocal osteomyelitis (CRMO) is a non-bacterial osteitis of yet unknown origin. Secondary to the absence of both high-titer autoantibodies and autoreactive T lymphocytes, and the association with other autoimmune diseases, it was recently reclassified as an autoinflammatory disorder of the musculoskeletal sy...
متن کاملChronic nonbacterial osteomyelitis in children: a retrospective multicenter study
BACKGROUND To determine the clinical presentation, current treatment and outcome of children with nonbacterial inflammatory bone disease. METHODS Retrospective multicenter study of patients entered into the Swiss Pediatric Rheumatology Working Group registry with a diagnosis of chronic nonbacterial osteomyelitis (CNO) and synovitis acne pustulosis hyperostosis osteitis (SAPHO) syndrome. The c...
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ژورنال
عنوان ژورنال: Pediatric Rheumatology
سال: 2013
ISSN: 1546-0096
DOI: 10.1186/1546-0096-11-s1-a220